Phosphorous compound and method of making same.



UNITED STATES PATENT OFFICE.

GUSTAV MARTELL, or GLAUOHAU', GERMANY. PHOSPHOROUS COMPOUND AND METHOD OF MAKING SAME-- Specification of Letters Patent. Application filed. March 10, 1905. Serial No. 249,495.

ratentea may 15, 1906.

To all whom it may concern:

Be it known that I, GUSTAV MARTELL,

physician, a subject of the German Emperor,

which are found in the yol of eggs and in vegetable matter or by those of inorganic origin.

My invention relates to a ipreparation of organic phosphorus obtained om the spinal cord-'-viz.,fromthe rolongedmarrowknown as the M edulla obl ongata, the upper cervical enlargement of the spinal cord, or Bulbus cemricalis, and the lower cervical enlargement or Bulb'us Z'wmbalis, and from the frontal and the temporal brain of strong healthy four to five year old cattle. It is in the re ons here mentioned that the largest accumu ations of phosphorus are to be found.

. My new preparation is best manufactured as follows: The parts stated of the spinal cord and brain'are de rived of their skin or membrane, washed with physiological common-salt solution, comminuted and stirred up to form a paste with the s irit of ether, known as spir. aether of the l lwrmacopoeia Germantco and consisting of one part to three parts spmt of specific gravity 0.805 to 0.809, which should be adde gradually. S irit of ether of the kind referred to is next added to this paste, which is then left a sufficient time in order to effect extraction, the whole being well shaken during the rooess. The entire mass is then filtered an the residue remaining on the filter still further pressed. The filtrate thus obtained is an extract of the substance of the brain and spinal cord. The ether contained in it can now be slowly evaporated over a water-bath or sand-bath at a temperature of, at most, 40 centigrade until a yellowish residue remains. To this residue a certain proportion of blood-serum spermin, and phosphate of sodium is added .very numerous toxins of metabolism,

under constant agitation until the entire mass has hardened. The proportions I prefer to use are substantially: residue, thirty grams; blood-serum, sixty grams; spermin, five grams; phosphate of sodium, five ams. The thus hardened mass is groun to a powder and is extremely rich in phosphorus.

By using this preparation as basis, m xed in certain proportion with glycerin sod um phosphate, s ermin, amylum, &c., pills, ointments, and t e like may be manufactured.

The new preparationis, in the first substitutional preparation, inasmuc affords a substitute for the phosphorus of the nervous system gradually being consumed in consequence of vital activity. It 1s furthermore an antitoxic preparation, since 1t forms lace, a

as it the natural physiological antitoxin for the form, owing to nervous exhaustion, and are classed together generally as leucomames. These toxins the new preparation by neutralization renders inactive.

What I claim is I. The process of manufacturing a preparation of organic hosphorus, consisting n removing the skin rom the marrow and bram of cattle, washing this marrow and bram in a solution of common salt, comminuting them,

stirring them to a pasty condition with the s irit of ether,known as spir. aether of the harmaco oeia Germanica, forming an extraction t ereof with spirit of ether of the said kind, filterin the mass, drivin ofi ether fromv the trate, and ming g the product with blood-serum, spermin, and phosphate of sodium, until the mass has hardened and is in a readily-pulverizable condition, all substantially as described.

2. The herein described organic phoshorous com ound, consisting of a dry, readily-pulveriza le mass obtained from mingled marrow and brain of cattle, blood-serum, s ermin, and sodium phosphate, substantlally as described.

In witness whereof I have hereunto signed my name, this 26th da of January, 1905, in the presence of two su scribing wltnesses.

GUSTAV MARTELIJ.

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